You are working in a pharmacy aseptic unit and have been asked to work out an estimated creatine clearance for a patient and then confirm the dose of medicine they require.
The patient is a female, aged 67 and weighs 60kg with a serum creatinine level of 100micromol / litre.



The medicine she requires can be given at full dose for a creatinine clearance of 90ml/min, a 50% dose reduction for a creatine clearance between 50-89ml/min and cannot have the medicine with a creatinine clearance of below 49ml/min.



Work out the patient's estimated creatinine clearance (ml/min) using the patient details above. Show all your working out.

ANSWERTo calculate the estimated creatinine clearance for this patient, we will use the Cockcroft-Gault equation. Since the patient is female, we will include the correction factor of 0.85 in the formula.The Cockcroft-Gault equation for females is:\text{Creatinine Clearance (mL/min)} = \frac{(140 - \text{age in years}) \times \text{weight in kg} \times 0.85}{\text{serum creatinine in } \mu\text{mol/L} \times 0.814}Where 0.814 is the conversion factor from \mumol/L to mg/dL multiplied by 72 (as the original equation used mg/dL).Now, let's plug in the patient's details: * Age = 67 years * Weight = 60 kg * Serum creatinine = 100 \mumol/L\text{Creatinine Clearance (mL/min)} = \frac{(140 - 67) \times 60 \times 0.85}{100 \times 0.814}\text{Creatinine Clearance (mL/min)} = \frac{73 \times 60 \times 0.85}{81.4}\text{Creatinine Clearance (mL/min)} = \frac{3723}{81.4}\text{Creatinine Clearance (mL/min)} \approx 45.74Answer: 45.74 mL/min

Answered by urprettysus | 2025-05-17