You are working in a pharmacy aseptic unit and have been asked to work out an estimated creatine clearance for a patient and then confirm the dose of medicine they require.
The patient is a female, aged 67 and weighs 60kg with a serum creatinine level of 100micromol / litre.
The medicine she requires can be given at full dose for a creatinine clearance of 90ml/min, a 50% dose reduction for a creatine clearance between 50-89ml/min and cannot have the medicine with a creatinine clearance of below 49ml/min.
Work out the patient's estimated creatinine clearance (ml/min) using the patient details above. Show all your working out.
Answer (1)
Estimated creatinine clearance = 45.5 ml/min[tex]________________________________[/tex]To estimate the patient's creatinine clearance (CrCl), we can use the Cockcroft-Gault equation, which is commonly used in clinical practiceCockcroft-Gault Equation (for females):[tex]\text{CrCl (ml/min)} = \frac{(140 - \text{age}) \times \text{weight (kg)} \times 1.04}{\text{serum creatinine (μmol/L)}}[/tex]Given:Age = 67 yearsWeight = 60 kgSerum creatinine = 100 µmol/LFemale → Use 1.04 as the correction factorSubstitute the values:[tex]\text{CrCl} = \frac{(140 - 67) \times 60 \times 1.04}{100}[/tex][tex]= \frac{73 \times 60 \times 1.04}{100}[/tex][tex]= \frac{4550.4}{100} = 45.504 \, \text{ml/min}[/tex]Result:Estimated creatinine clearance = 45.5 ml/minDosing Recommendation:Since her CrCl is below 49 ml/min, she should NOT receive the medicine according to the dosing guidelines provided.[tex][/tex]
