Why do cancer cells exhibit uncontrolled growth
Answer (1)
Cancer cells exhibit uncontrolled growth due to a combination of genetic mutations that disrupt the normal regulation of the cell cycle. These mutations often involve proto-oncogenes, which, when mutated into oncogenes, become overly active in promoting cell division. Simultaneously, mutations inactivate tumor suppressor genes, which generally inhibit cell growth and induce programmed cell death when necessary. This loss of both positive and negative growth controls allows cancer cells to divide relentlessly, ignoring the signals that would normally stop or slow down cell proliferation. Furthermore, cancer cells often develop mechanisms to evade apoptosis and stimulate the formation of new blood vessels (angiogenesis) to ensure a constant supply of nutrients and oxygen, facilitating their continuous and unchecked expansion.
